Observational analysis shows adverse childhood experiences decrease white matter integrity in exposed individuals, indicating PTSD diagnosis moderates neural tract disruption.
Adverse childhood experiences (ACE) are well-known risk factors for the development of PTSD later in life. The overall effect of ACE on WM integrity and the moderation effect of PTSD in this relation are still being researched. Using a total of 78 participants with any form of ACE, we show that ACE was negatively correlated with WM integrity in the genu and body of the corpus callosum and the bilateral uncinated fasciculus after controlling for overall psychological burden. The overall strength of this effect changed in corpus callosum and uncinated fasciculus when PTSD was added as a moderator variable.
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Nkrumah et al. (2024) studied this question.
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