The exchange weighting and robustness to B0-inhomogeneities are essential properties for accurate CEST-MRI saturation measurements. Therefore, we investigated these properties for a new numerical optimized saturation pulse train and for state-of-the-art saturation pulse strategies in simulation and phantom measurements. We have found that the optimized pulse train generates superior CEST contrast and has very high stability against B0-inhomogenities while maintaining the natural shape at the water peak which improves CEST-spectrum fitting and B0-correction.
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Stilianu et al. (2024) studied this question.
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