The purpose of this study was to explore the feasibility of preoperative non-invasive evaluation of immunohistochemical indexes of hepatocellular carcinoma, CK19 and Hep par-1 positive, with Fractional Order Calculus (FROC) model using nude mice model. Results showed that the diffusion coefficient D and fractional order derivative in space β had statistically significant differences and good diagnostic performances between the CK19 and Hep par-1 positive groups. These finding showed that FROC is useful diffusion model and D and β are useful biomarkers in liver cancer with expression of the immunohistochemical indexes CK19 and Hep par-1.
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Xie et al. (2024) studied this question.
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