Brownian superparamagnetic iron oxide nanoparticles enable therapeutic cell viability monitoring with Magnetic Particle Imaging

Molecular imaging tools can noninvasively track cells in vivo. However, no techniques today can rapidly monitor cell therapies to allow for nimble treatment optimization for each patient, the epitome of Personalized Medicine. Magnetic Particle Imaging (MPI) is a new tracer imaging technology that could soon provide MDs unequivocal therapy treatment feedback in just three days. MPI with Brownian SPIOs shows promise towards noninvasive sensing of cell viability via viscosity changes in apoptotic cells. This unique ability could greatly improve the efficacy of cell therapies by enabling rapid personalization of the treatment.