Association of peripheral inflammation with disrupted brain functional network topology in bipolar disorder

This study provided preliminary evidence of the association between disrupted brain functional network topology and neuroinflammation in BD. The current study demonstrated disrupted topological organization in the whole brain and regional connectivity was associated with inflammatory cytokines of the IL-4, IL-8 and IL-10 levels in BD. Moreover, our results indicated that higher IL-4 levels and impaired regional connectivity in the temporal pole may be associated with the severer depressive symptoms in BD.