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A T1-only method to extract a quantitative myelin water fraction, utilizing a 3D radial k-space MPnRAGE sequence that reconstructs hundreds of different inversion time (TI) images in the same scan used for high-resolution T1-weighted morphometry was developed. To address high sensitivities to additive image noise of this complex model, a multi-pass fitting algorithm was prototyped that provides educated initial guesses and constraints on the underlying parameters.
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Weaver et al. (2024) studied this question.
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