Multimodal structural and functional features underlying cognitive function in first-episode major depressive disorder

Multimodal joint differences in the right dorsal lateral prefrontal cortex, bilateral superior and inferior parietal lobules, and bilateral calcarine cortex contributed to identification of patients with major depressive disorder (MDD), offering promise in the multimodal psychoradiological characterization for MDD diagnosis. In addition, widespread gray matter alterations across neocortex were associated with cognitive impairments, and partially mediated the age-related cognitive difficulties associated with MDD, deepening the understanding of the relationships between brain alterations and neurocognitive changes in MDD.