White Matter Structural Connectivity is Associated with Spectral Coherence and Phase Synchronization Measured by Intracranial EEG

Using high quality atlas of the structural connectome, and direct recording of neuronal activity by stereotactic-EEG (SEEG), this study investigated the relationship between neuronal signal connectivity at different seizure stage and the white matter scaffold. The results show electrical signal spectral coherence and phase synchronization are significantly stronger between structurally connected nodes within short distance, while at the time of pre-seizure and seizure onset, high frequency (>80Hz) signal may propagate through longer distance with structural connections.