Differentiation of progressive disease from pseudo-progression using Synthetic MRI and MUSE-DWI in patients with glioblastoma.

This work sought to investigate the performance of synthetic MRI(Sy-MRI) and MUSE-DWI in differentiating progressive disease (PD) from pseudo-progression (PsP). It was concluded that the pre-contrast T1(T1-pre) and post-contrast T1(T1-Gd) from synthetic MRI can be used as novel quantitative imaging biomarkers for discriminating PD from PsP. The combination of T1-pre, T1-Gd and ADC may explore as an effective strategy to improve the ability for discriminating PD from PsP, and provide a basis for clinical follow-up diagnosis and treatment.