Time Course Changes of Synthetic Relaxation Time during Neoadjuvant Chemotherapy in Breast Cancer.

This study investigated the time course changes of synthetic magnetic resonance imaging (MRI) parameters (T1/T2 relaxation time [T1/T2], proton density [PD]) during neoadjuvant chemotherapy (NAC) and evaluate their value as predictors for pathological complete response (pCR) in locally advanced breast cancer. The results showed that median synthetic T1/T2/PD and tumor diameter generally decreased throughout NAC. And the Change of synthetic T1 after the first cycle of NAC may be an early predictor for NAC response in locally advanced breast cancer during whole treatment cycles. However, its predictive ability is significantly affected by histological grades.