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We aimed to optimize MRI acquisition with 1mm isotropic resolution and Quantitative Susceptibility Mapping (QSM) reconstruction for prostate clinical research. Acquisition parameters optimized in two subjects included fat-water phase artifact removal, parallel imaging acceleration factor, resolution and number of echoes. QSM masking, background field removal and susceptibility calculation were optimized in six subjects and three prostatectomy specimens. In-phase acquisition removed more fat-water phase artifacts than post-processing. VSHARP and excluding rectal gas reduced residual background fields and Iterative Tikhonov regularization reduced noise. This optimized (8.5 minute) protocol and pipeline will allow incorporation of prostate QSM in clinical research studies.
Muralidharan et al. (Wed,) studied this question.