Around 200,000 veterans of the 1991 Gulf War (GW) suffer from GW illness (GWI). GWI is a poorly understood chronic medical condition, characterized by multiple symptoms. One factor that hampers mechanistic investigations into GWI is that there is considerable heterogeneity in symptoms across the GW veteran population. Only one case definitions of GWI addresses this heterogeneity. The Haley GWI case definition addresses this by further breaking down GWI into three main syndrome variants (Syn1, Syn2, and Syn3) based on factor analysis of symptoms presented by GWI veterans. In this study, we extracted rsfMRI connectomics biomarkers for different syndromes of GWI.
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Yang et al. (2024) studied this question.
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