Parametrized macromolecule models in the brain 1H MRS quantification: Effect of the baseline spline on quantification uncertainty and precision

Parametric macromolecule (MM) models can improve the quantification of brain 1H-MRS. We quantified a publicly available repeated-acquisition dataset with LCModel and applied a parametric MM model in conjunction with four different settings for spline node distance and compared the quantification results. Coefficients of variation, average Cramér-Rao lower bound, repeatability, and reproducibility were estimated. A moderate effect of the baseline spline was shown.