Brainstem nuclei are involved in several vital functions; impairment in their structure and function is manifested in several clinical conditions of elderly humans, including sleep/arousal/movement/vestibular/anxiety disorders, chronic pain and altered autonomic functions. Brainstem evaluation in health and disease is currently limited by the difficulty of localizing these regions in conventional MRI. We developed an in-vivo probabilistic atlas of 31 brainstem nuclei in elderly humans by the use of multi-contrast 7 Tesla MRI in 15 elderly subjects and of an existing brainstem nuclei atlas in younger adults. This atlas can be applied to conventional MRI and aid brainstem investigation in aging.
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Koley et al. (2024) studied this question.
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