Brain glutathione levels decrease with age and correlate with cognitive function

Cognitive impairment and the improvement of oxidative stress are common in the aged. GSH is a key player to defend oxidative stress and avoid ferroptosis. We aim to explore the variation of brain GSH levels with age including anterior cingulate cortex, posterior cingulate cortex and occipital cortex, and to test whether GSH levels in these regions are associated with cognitive function. Our findings indicate that oxidative stress and ferroptosis abnormality caused by the decreased GSH levels may contribute to cognitive decline of the aged without a regional specificity manner.