Preclinical study demonstrates restored corticolimbic connectivity and enhanced memory in an Alzheimer's disease mouse model, suggesting therapeutic potential for symptom management.
Intermittent theta-burst stimulation (iTBS) has been hypothesized to be a more effective paradigm for deep brain stimulation (DBS) in treating various neurological disorders by altering neuronal circuits. However, the effect of iTBS in improving memory deficits in AD patients remains unknown. Combining iTBS in central thalamus (CT-iTBS) with functional magnetic resonance imaging, our results demonstrated the restoration of brain functional connectivity (FC) in corticolimbic circuit of AD mice model, accompanied with enhancing memory cognitive function in novel object recognition test and T-maze test. These results revealed that CT-iTBS could be an effective treatment for improving symptoms of individuals with AD.
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Lin et al. (2024) studied this question.
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