A hallmark of Alzheimer's Disease (AD) is spatial disorientation, such as getting lost in new locations. A potential cause is disrupted exchange between egocentric and allocentric reference frames, in which the parietal and retrosplenial cortex have roles. This study aimed to examine rs-fMRI and DTI in relationship with coordination between reference frames in a transgenic AD rat model. Behavioral and DTI data suggest that both age and genotype lead to declines in action-orientation performance with alterations appearing at 5 mon, and at 6 mon structurally with profound changes developing longitudinally across multiple ROI.
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Radovich et al. (2024) studied this question.
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