Brain temperature is an important physiological parameter that both reflects and modulates brain activity, but current in vivo thermometry methods are invasive and/or impractical for small animals. We present a minimally invasive method for measuring blood and brain temperature in mice using Tm-DOTMA and characterize the relationship between brain and blood temperature under isoflurane anesthesia. Brain temperature was strongly correlated and approximately equal to the temperature of the inflowing arterial blood, possibly reflecting the vasodilatory and metabolic suppressive effects of isoflurane. Application of this method with alternative anesthesia approaches would provide insight into brain temperature regulation in health and disease.
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Gazdzinski et al. (2024) studied this question.
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