Noninvasive diagnosis of clinically significant portal hypertension with MR elastography, T1, and T1ρ mapping of the liver and spleen

In this prospective study, we explored the diagnostic value of MR elastography (MRE) as well as T1-pre and post-gadoxetate contrast at the hepatobiliary phase and T1ρ mapping of the liver and spleen for noninvasive diagnosis of clinically significant portal hypertension (CSPH) in patients with liver disease. 2D MRE liver (r=0.457, p<0.001) and spleen stiffness (r=0.438, p<0.001) showed a strong significant correlation with portal pressure measurement based on hepatic venous pressure gradient (HVPG). 2D MRE spleen stiffness outperformed other imaging parameters for prediction of CSPH [AUC = 0.867 (0.764-0.970)].