Intra-Subject Stability and Reproducibility of 7 T FID-CRT-MRSI

We evaluated the intra-subject stability of CRT-FID-MRSI at 7 T in a cohort of 15 volunteers. Two magnetic resonance spectroscopic imaging acquisitions were performed consecutively and metabolite concentration estimates (CEs) were calculated using internal water referencing. The resulting metabolic maps were segmented in 55 brain regions. For analysis, the CEs of both acquisitions were compared and coefficients of variations (CVs) were calculated. We saw high stability in almost all volunteers, with CVs being well below 5% in the brain regions generally associated with good data quality.