Optimization of T1-Weighted DANTE-SPACE for Intracranial Vessel Wall Imaging at 7T

This is the authors' abstract. We don't add key points for this paper.

MR vessel-wall-imaging (VWI) is used clinically for noninvasive characterization of vessel wall pathology. The DANTE preparation module has been combined with conventional 3D-T1W-SPACE to achieve better slow-flow-suppression. 7T could further improve VWI by its increased SNR and spatial-resolution. Here we sought to optimize DANTE preparation module for T1W-SPACE at 7T. Simulations were done to determine the optimal parameters for the DANTE module. Human scans showed that the optimized T1W- DANTE-SPACE at 7T efficiently suppressed slow-blood-flow in both intracranial arteries and veins, and in turn improved wall contrast compared with conventional T1W-SPACE.