Quantitative choroid plexus and bulk cerebrospinal fluid metrics in older adults with and without Alzheimer’s disease

The goal of this work is to characterize changes in the choroid plexus (ChP) and aqueductal cerebrospinal fluid dynamics in patients with Alzheimer’s disease utilizing arterial spin labeling (ASL) and phase contrast (PC), respectively. We observed that across all participants, ChP hypertrophy was associated with reduced ChP perfusion. However, we did not observe differences in ChP perfusion or net CSF flow between AD and healthy cohorts. The observed increase in peak CSF flow with age, despite the general decrease in ChP perfusion with age, suggests that the ChP performs functions beyond simply increasing or decreasing CSF production.