Phase-Based Registration for Visualisation of Pulsatile Brain Motion

Pulsatile brain motion is a valuable tool in understanding injury and congenital disorders. These pulsatile motions have a typical magnitude of < 1 pixel. Amplified MRI (aMRI) amplifies the pulsatile motion to the point of visibility, enabling qualitative examination. However, the amplification in frequency space results in nonlinear distortion of motion preventing the recovery of unaugmented displacements. Here, we propose using phase-based subpixel registration. This methodology enables the recovery of displacement quantification of pulsatile brain motion.