Accelerating 3T MRI standardized protocol for detection of Amyloid Related Imaging Abnormality (ARIA) using Philips SmartSpeed

Amyloid Related Imaging Abnormality (ARIA) was reported in 40% of patients treated with anti-amyloid beta drugs in phase 3 trials. It is expected to be a significant factor in the clinical application of new Alzheimer’s Disease (AD) modifying therapies and requires standardized and practical imaging. By employing Compressed-SENSE (CS-SENSE) and newer deep learning based SmartSpeed to accelerate acquisition we created a robust MRI protocol that can be completed in under ten minutes without loss of any image quality. This accelerated protocol can provide a clinically feasible strategy for scanning large populations.