Abnormal functional connectivity between white and gray matter is associated with hearing loss and cognitive dysfunction in presbycusis

Presbycusis is characterized by high-frequency hearing loss and is closely related to cognitive decline. In this study, we aimed to explore the connectivity changes of WM and GM in the brains of presbycusis patients and their relationship with cognitive impairment and hearing loss. The results of this study indicated that the functional connectivity of WM and GM was abnormal in presbycusis patients, mainly in the PLIC, BCC, STG, par opercularis, etc. These changes might be associated with auditory processing and cognitive compensation. This study may provide new insights into the underlying neural mechanisms between presbycusis and cognitive impairment.