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Excessive alcohol intake seriously damages the brain. Previous animal studies reported that the glymphatic system, which is a brain waste clearance system via the cerebral spinal fluid, is affected by chronic high alcohol consumption. Glymphatic dysfunction is related to cognitive impairment. The changes of diffusivity along the perivascular space (ALPS) indices associated with heavy, moderate, and no‑alcohol intake and executive function with or without aldehyde dehydrogenase 2 (ALDH2) rs671 polymorphism was evaluated. The present study revealed the glymphatic function and executive function decline in heavy drinkers. Furthermore, ALDH2 rs671 variants may increase vulnerability to alcohol-induced glymphatic dysfunction.
Morita et al. (2024) studied this question.