Sequential PET/MR reveals evidence of parasagittal dural hypertrophy in the setting of elevated Aβ burden in adults with Alzheimer’s disease

A pathological hallmark of Alzheimer’s disease (AD) is the elevated aggregation of protein amyloid-β (Aβ) in the cerebrum. Recent studies have suggested a role for the parasagittal dural (PSD) space in cerebrospinal fluid (CSF) egress and associated protein clearance. A fully connected neural network was used to generate PSD segmentation masks from 3D T2-weighted turbo-spin-echo data to assess the relationship between PSD space volume and Aβ burden estimated by 11C-Pittsburgh Compound B in AD participants. PSD space hypertrophy was significantly associated with elevated Aβ levels and was localized to the frontal and parietal subsegments of the PSD.