Lower limb muscle-water T2 as a marker of disease severity and progression in amyotrophic lateral sclerosis

This is the authors' abstract. We don't add key points for this paper.

Using optimised maximum-likelihood-estimation extended-phase-graph-model relaxometry in ALS patients, elevated muscle water T2 (T2m) were revealed for all calf muscles and most thigh muscles vs. controls, with evidence of sparing of particular muscles. Similar but les consistent increases were seen in the associated fat fraction (ffa, relaxometry estimated). T2m correlated significantly with both functional rating scores and myometry, most consistently at the calf level. Associated ffa changes and correlations were less significant.