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May 20, 2011Magnetic Resonance in MedicineOpen Access

The IDEAL-CPMG MRI sequence successfully separated fat and water components, revealing uniform maps in healthy volunteers and muscle-specific patterns of fat infiltration and edema in myositis.

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Population

Phantoms, healthy volunteers, and a patient with inclusion body myositis

Design

Other

Key result

The IDEAL-CPMG MRI sequence successfully separated fat and water components, revealing uniform maps in healthy volunteers and muscle-specific patterns of fat infiltration and edema in myositis.

Authors

RJRobert L. JaniczekGGGiulio GambarotaCSChristopher D. J. Sinclair

Discussion

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Overview

May aid quantitative muscle assessment in myositis; leaves open clinical adoption pending larger validation studies.

Structured PICO

P
Population
Healthy volunteers and a patient with inclusion body myositis evaluated using a novel MRI sequence.
E
Exposure
IDEAL-CPMG sequence (combines iterative decomposition of water and fat with echo asymmetry and least squares estimation with a Carr-Purcell-Meiboom-Gill-sequence)
O
Outcome
T2_w, T2_f, and T2-corrected fat fraction mapssurrogate

The novel IDEAL-CPMG MRI sequence allows for simultaneous quantification of water T2 and fat fraction, overcoming limitations of microscopic fat infiltration in assessing neuromuscular diseases.

Cite This Study

Janiczek et al. (2011) studied Neuromuscular diseases (inclusion body myositis). IDEAL-CPMG MRI sequence was evaluated on T2_w and T2_f quantification and T2-corrected fat fraction map. The IDEAL-CPMG MRI sequence successfully separated fat and water components, revealing uniform maps in healthy volunteers and muscle-specific patterns of fat infiltration and edema in myositis.

synapsesocial.com/papers/6a7ae5d435e7b6bcc6892d16https://doi.org/10.1002/mrm.22916
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