Imaging water exchange in the choroid plexus using T2-prepared long TE Fluid-Attenuated Inversion Recovery

The choroid plexus (CP) plays a key role in brain homeostasis and waste clearance as the main source of CSF production in the brain. However, this small structure sitting in the lateral ventricles is not well characterized, including its dysfunction or impairment in several pathologies or just normal aging. Water exchange measurement using various methods has been proposed to evaluate structural but also functional properties of the CP such as ASL or other spin labeling strategies mainly in rodents. In this work, we propose a new look into water exchange between CP and CSF using T2-prepared, long TE Fluid-Attenuated-Inversion-Recovery (FLAIR).