Multi-site study reports associations between cerebrovascular reactivity MRI and cognitive function in older adults, highlighting its potential as a small vessel disease biomarker.
Small vessel disease (SVD) related vascular contributions to cognitive impairment and dementia (VCID) represent a major factor in cognitive decline in older adults. However, there has not been a validated biomarker for the diagnosis and treatment monitoring of this condition. Recently, the US National Institute on Neurological Disorders and Stroke (NINDS), a branch of NIH, funded a MarkVCID consortium, the goal of which is to identify and validate clinical-trial-ready biomarkers for VCID. Cerebrovascular reactivity (CVR) MRI was one of the selected biomarkers that underwent multi-site testing. The present work reports the relationship between CVR and cognitive function, and examines whether the pre-specified hypothesis can be reproduced at each of the sites.
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Liu et al. (2024) studied this question.
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