Depression Related Structural Changes Based on 3D Brain MRI and Neural Fingerprint Assisted Segmentation

This study focused on the slight quantitative changes of brain structures based on the high-resolution brain MRI and automatic segmentation with neural fingerprint technology for whole-brain of depressive patients. We found the volume changes of specific regional sub-structures, which were related to emotion and spirit, such as the cingulate gyrus, cuneiform lobe, hippocampus, et al before clinical diagnosis. Depression revealed the gender difference. The male depressions were more sensitive to hippocampus, while female’s were more sensitive to entorhinal cortex. It might indicate ovarian hormone fluctuations modulate women’s susceptibility to stress, brain structure/function, and inflammatory activity and reactivity.