This study shows 3D-T1rho mapping of the human brain using optimized variable flip-angles (OVFAs) and weighted spin-lock pulses (WSLP). Our preliminary results suggest that the proposed sequence based on OVFAs and WSLP can improve SNR by almost 3X in brain T1rho mapping, reduces data acquisition time by half, and improve the mean of normalized absolute deviation (MNAD) compared to MAPSS sequence for the same application.
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Zibetti et al. (2024) studied this question.
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