We proposed an efficient magnetization-prepared gradient echo (MP-GRE) sequence that uses optimized variable flip-angles (OVFA) to reduce acquisition time by 4x while increasing SNR when compared to magnetization-prepared angle-modulated partitioned k-space spoiled GRE snapshots (MAPSS), typically used for T1rho mapping. The proposed OVFA based sequence can improve the spatial resolution of T1rho mapping by 4x, with nearly same SNR and scan time as MAPSS.
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Zibetti et al. (2024) studied this question.
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