The aim of this study was to investigate sex differences in brain structure at baseline and sex differences in longitudinal changes at follow-up between female and male PD patients after excluding the expected effects of age and sex. At baseline, male PD patients exhibited significantly lower brain volume and decreased cortical thickness than age-matched female PD patients. At follow-up, these sex differences remained stable and analogous progressive brain atrophy with no sex interaction were found in male and female PD patients, suggesting similar trend in disease progression between sexes over time.
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Li et al. (2024) studied this question.
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