Development and Analysis of MRI-Derived Carpal Motion Data Elements

We present the construction and analysis of dynamic carpal data elements derived from 4D-MRI of the moving wrist. Across a clinically asymptomatic cohort of 31 subjects, dynamic data elements were constructed from capitate-normalized profiles of the scaphoid and lunate bones in a subject-specific radius-based coordinate system. Along with computing stability estimates of these measures, they are utilized to perform preliminary logistic regression modeling of radiologically-identified asymptomatic abnormalities within the study cohort. The results of this analysis suggests that the derived data elements have promising capabilities for characterizing carpal pathology and abnormalities.