Quantitative susceptibility source separation improves the reader agreement in the identification of MS paramagnetic rim lesions

Multiple Sclerosis (MS) is an autoimmune disorder characterized by focal inflammatory demyelination. Paramagnetic rim lesions (PRLs) form an important subset of chronic active MS lesions that show a hypocellular core and persistent glial inflammation and continuing myelin damage at the rim on histopathology. PRLs are a critical clinical target for MS therapy. Our goal in this project is to improve overall detection of PRLs through utilization of quantitative paramagnetic source maps.