Many interesting metabolites, for instance adenosine triphosphate (ATP), glutathione (GSH) and homocarnosine (hCs), have resonances in the downfield range (>4.7 ppm) in 1H-MRS. Previous studies have studied the downfield spectra of metabolites in human brain using single-voxel spectroscopy (SVS) and, most recently, 2D one-slice MRSI. The study presents a 3D whole brain mapping sequence suited for downfield metabolites which does not require water suppression pulses.
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Weng et al. (2024) studied this question.
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