Brain MRI phenotypes of glioblastomas are suggestive of overall patient survival

Despite multimodal anti-tumor treatment, glioblastomas typically progress, yet identifying true tumor progression on MRI-scans is challenging. We aimed to establish brain MRI phenotypes of glioblastomas by combined analysis of radiological scoring of structural and perfusion tumor characteristics 3-months post-radiotherapy. Hierarchical clustering analysis method was applied to group patients by similar tumor characteristics and it was analyzed whether these groups showed differences in tumor progression and overall survival outcome. Four distinct MRI phenotypes of glioblastoma were established and showed between-group differences in median overall survival time.