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May 8, 2026Neuro-Oncology AdvancesOpen Access

Prediction Of Treatment Failure in Patients with Glioblastoma with Perfusion MRI and Molecular Biomarkers

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Authors

RLRiccardo LudovichettiJVJordan M VilliersGBGergely Bertalan

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Overview

Retrospective analysis identifies early treatment failure predictors in glioblastoma, suggesting targeted therapies.

Key Points

  • This study aims to identify predictors of early treatment failure in glioblastoma and their impact on overall survival.
  • Retrospective analysis of 62 patients with glioblastoma in a single center.
  • Patients underwent DSC- and DCE-MRI before surgery and radiochemotherapy.
  • Multivariable logistic regression models analyzed associations with treatment outcome.
  • 44 patients (71%) were identified as non-responders; 18 patients (29%) were responders.
  • Elevated pretreatment rCBV and Ktrans predicted treatment response with P < 0.05.
  • MGMT promoter methylation status was linked to long-term survival, with HR 0.31, 95% CI 0.17–0.55, P < 0.001.

Cite This Study

Ludovichetti et al. (2026) studied this question.

synapsesocial.com/papers/69fd7fcdbfa21ec5bbf086ffhttps://doi.org/10.1093/noajnl/vdag119
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Molecular Profiling to Understand Treatment Resistance and Response in Glioblastoma2024
  2. 2Prediction of Survival in Surgically Treated Glioblastoma Multiforme Utilizing DTI and Contrast-Enhanced MRI2025
  3. 3Longitudinal Evaluation of DCE-MRI as an Early Indicator of Progression after Standard Therapy in Glioblastoma2024 · 2 citations
  4. 4Preoperative MR Perfusion and Intraoperative MR Imaging in Predicting Surgical Resectability and Quality of Life Outcomes in High-Grade Glioma Patients: A Prospective Cohort Analysis and Case Study2026
  5. 5Diffusion-weighted imaging and dynamic susceptibility contrast-enhanced perfusion-weighted imaging of the non-enhancing peritumoral region predict overall survival in glioblastoma2025