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April 21, 2026CureusOpen Access

Preoperative MR Perfusion and Intraoperative MR Imaging in Predicting Surgical Resectability and Quality of Life Outcomes in High-Grade Glioma Patients: A Prospective Cohort Analysis and Case Study

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Authors

OOOmowumi OladipoPhiladelphia College of Osteopathic MedicineCRClayton RawsonPhiladelphia College of Osteopathic MedicineKCKyril L ColeUniversity of Utah

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Overview

This prospective pilot study evaluates MR imaging's ability to predict survival and quality of life in high-grade glioma patients, suggesting early QoL measures may be informative.

Key Points

  • The study aims to assess if preoperative MR perfusion and intraoperative MRI can predict surgical resection extent and patient outcomes in high-grade glioma cases.
  • Conducted a prospective analysis on high-grade glioma patients following advanced MRI-guided surgeries.
  • Compared preoperative cerebral blood volume and flow with postoperative quality of life metrics and overall survival outcomes.
  • Patients were categorized based on overall survival to analyze differences in imaging parameters.
  • Patients with higher preoperative CBV and CBF experienced significantly worse overall survival.
  • The mean extent of resection during iMRIs was very high, showing no difference in EOR between good and poor outcome groups.
  • Quality of life metrics declined notably in patients with worse survival outcomes in areas like social well-being.

Cite This Study

Oladipo et al. (2026) studied this question.

synapsesocial.com/papers/69e7138bcb99343efc98d04fhttps://doi.org/10.7759/cureus.107306
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Prognostic relevance of radiological findings on early postoperative MRI for 187 consecutive glioblastoma patients receiving standard therapy2024 · 4 citations
  2. 2Intraoperative Magnetic Resonance Imaging in Glioma Surgery: A Single-center Experience2024
  3. 3Effect of intraoperative neuromonitoring changes and post-operative neurological deficits on long-term survival in patients with high-grade gliomas: A retrospective analysis2026
  4. 4Preoperative assessment of intratumor heterogeneity using intravoxel incoherent motion MRI for survival prediction in high-grade gliomas: a feasibility study2026
  5. 5Prediction Of Treatment Failure in Patients with Glioblastoma with Perfusion MRI and Molecular Biomarkers2026