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March 3, 2026Journal of Neuro-Oncology DiscoveryOpen Access

Effect of intraoperative neuromonitoring changes and post-operative neurological deficits on long-term survival in patients with high-grade gliomas: A retrospective analysis

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Authors

AMApurv MehraARAkshaya RamanNMNandhni Murugesan

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Overview

This retrospective analysis examines survival outcomes in high-grade glioma patients with intraoperative monitoring changes and post-operative deficits, indicating critical prognostic markers.

Key Points

  • The study aims to determine if intraoperative neuromonitoring changes and post-operative neurological deficits are independently linked to long-term survival in high-grade glioma patients.
  • Retrospective analysis of 224 patients undergoing high-grade glioma resection
  • Stratification into groups based on intraoperative neuromonitoring changes and post-operative deficits
  • Survival analysis using Kaplan–Meier curves and Cox proportional hazards models
  • Adjustment for age, gender, preoperative Karnofsky Performance Status, and baseline neurological deficits
  • Patients with IONM changes only had a 24-month mortality rate of 72.7%
  • Those with both IONM changes and deficits had a mortality rate of 55.9%
  • Significantly worse survival outcomes for IONM-only group (p = 0.004)
  • Cox regression analysis indicated that IONM changes were independently associated with increased mortality (HR 3.94, 95% CI 1.69–9.21)

Cite This Study

Mehra et al. (2026) studied this question.

synapsesocial.com/papers/69a67e0ef353c071a6f09ef5https://doi.org/10.1007/s44499-026-00004-9
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1A Permanent but Not Transient Postoperative Deficit Has Impact on OS and PFS in IDHwt-Glioma Patients2026
  2. 2Application value of intraoperative electrophysiological monitoring in cerebral eloquent area glioma surgery: a retrospective cohort study2024 · 1 citations
  3. 3Preoperative MR Perfusion and Intraoperative MR Imaging in Predicting Surgical Resectability and Quality of Life Outcomes in High-Grade Glioma Patients: A Prospective Cohort Analysis and Case Study2026
  4. 4Establishment of Different Intraoperative Monitoring and Mapping Techniques and Their Impact on Survival, Extent of Resection, and Clinical Outcome in Patients with High-Grade Gliomas—A Series of 631 Patients in 14 Years2024 · 2 citations
  5. 5Extent of resection and perioperative neurological status as prognostic markers in glioblastoma: a population-based study2026 · 1 citations