Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
July 29, 2026Journal of Clinical MedicineOpen Access

A Permanent but Not Transient Postoperative Deficit Has Impact on OS and PFS in IDHwt-Glioma Patients

View Full Paper
Ask AI
Bookmark
Share

Authors

JKJulia KlingenschmidMDMatthias DemetzNPNadine Pichler

Discussion

Loading...

Member takes

Overview

Retrospective review demonstrates persistent neurological deficits predict worse outcomes in glioma patients, suggesting critical impact on prognosis.

Key Points

  • This study aims to determine the differing impacts of transient versus persistent postoperative neurological deficits on overall and progression-free survival in glioma patients.
  • Retrospective review of 496 glioma patients undergoing surgery
  • Neurological function assessed preoperatively, immediately postoperatively, and at follow-up (3-6 months)
  • Analysis of survival outcomes in relation to the persistence of neurological deficits
  • Median OS for all patients was 34 months (95% CI, 30-38) with no significant association between preoperative deficits and OS.
  • Persistent postoperative deficits were linked to significantly shorter OS and PFS in IDH-wild-type glioma patients (p < 0.001).
  • New neurological deficits observed at follow-up correlated with worse OS and PFS exclusively in IDH-wild-type tumors (p < 0.001).

Cite This Study

Klingenschmid et al. (2026) studied this question.

synapsesocial.com/papers/6a69a2fcc8da07d9defa71c3https://doi.org/10.3390/jcm15155835
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Incidence and Survival of IDH-Wildtype Glioblastoma and IDH-Mutant Astrocytoma by Treatment and Sex: A Regional Study in Spain (2011–2021)2025 · 3 citations
  2. 2Risk of Postoperative Hemorrhage After Glioma Surgery in Patients with Preoperative Acetylsalicylic Acid2024 · 4 citations
  3. 3Prognostic associations of steroid use in patients with glioblastoma: a population-based study2026 · 1 citations
  4. 4The effects of new or worsened postoperative neurological deficits on survival of patients with glioblastoma2016 · 216 citations
  5. 5Postoperative ischemia and neurological deficits after glioma resection: A systematic review and meta-analysis2025 · 1 citations