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November 20, 2025Neuro-Oncology AdvancesOpen Access

The Impact of Postoperative Ischemic Changes on Survival Outcomes in IDH-wildtype Glioblastoma

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Authors

NGNeslihan Nisa GeçiciAHAhmed HabibWHWalaa Hamza

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Overview

Retrospective review shows infarct volume impacts progression-free survival and overall survival in IDH-wildtype glioblastoma patients, highlighting ischemia implications.

Key Points

  • This study aims to clarify the prognostic impact of postoperative ischemic changes on survival outcomes in glioblastoma patients.
  • Retrospective review of 451 IDH-wildtype GBM patients who underwent resection from 2013 to 2024.
  • Diffusion-weighted imaging was performed within 72 hours postoperatively to assess ischemic changes.
  • Survival analyses for progression-free survival and overall survival utilized Kaplan–Meier and Cox regression models.
  • Large infarcts associated with shorter median progression-free survival (7.0 months) and overall survival (14.0 months).
  • Infarct volume independent predictor of reduced overall survival per cubic centimeter increase (HR = 1.02).
  • Large infarcts predictive of shorter progression-free survival (HR = 1.4) and overall survival (HR = 1.7).

Cite This Study

Geçici et al. (2025) studied this question.

synapsesocial.com/papers/6924f074c0ce034ddc34fac6https://doi.org/10.1093/noajnl/vdaf235
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1SURG-72. Ischemia Predicts Poorer Survival in Glioblastoma Independent of Neurological Deficits2025
  2. 2200 DWI and ADC Changes in Patients With Glioblastoma IDH-Wild Type Following Surgical Tumor Resection2024 · 1 citations
  3. 3Extent of Resection and Survival in IDH-Wildtype Glioblastoma: A Dual-Center Retrospective Study2026 · 1 citations
  4. 4Anatomical and subcortical invasiveness in diffuse low-grade astrocytomas differ between IDH status and provide prognostic information2024 · 1 citations
  5. 5A Permanent but Not Transient Postoperative Deficit Has Impact on OS and PFS in IDHwt-Glioma Patients2026