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November 1, 2025Neuro-OncologyOpen Access

SURG-72. Ischemia Predicts Poorer Survival in Glioblastoma Independent of Neurological Deficits

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Authors

NGNeslihan Nisa GeciciAHAhmed HabibAAAllyson Andrews

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Overview

Retrospective analysis links postoperative ischemia to poorer survival without neurological deficits in glioblastoma, suggesting a need for improved surgical strategies.

Key Points

  • To investigate the relationship between postoperative ischemia and survival outcomes in glioblastoma patients.
  • Retrospective analysis of patients with glioblastoma from 2013 to 2024 with postoperative imaging within 72 hours.
  • Ischemic changes were categorized based on median infarct volume into small and large confluent ischemic changes.
  • Outcomes measured included progression-free survival and overall survival.
  • 45% of patients exhibited postoperative ischemic changes.
  • Significant increase in new or worsened neurological deficits in patients with ischemic changes.
  • Patients with larger ischemic changes had shorter progression-free survival (6 months) and overall survival (14 months).

Cite This Study

Gecici et al. (2025) studied this question.

synapsesocial.com/papers/6925436cc0ce034ddc3585eehttps://doi.org/10.1093/neuonc/noaf201.1626
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The Impact of Postoperative Ischemic Changes on Survival Outcomes in IDH-wildtype Glioblastoma2025
  2. 2200 DWI and ADC Changes in Patients With Glioblastoma IDH-Wild Type Following Surgical Tumor Resection2024 · 1 citations
  3. 3Prediction of Overall Survival in Glioblastoma Using Early Postoperative Reduction in FLAIR Lesion Volume After Gross Total Resection2026
  4. 4OS05.7.A NEUROSURGERY IN GLIOBLASTOMA INDUCES CELL PLASTICITY, THERAPY RESISTANCE AND IMMUNOSUPPRESSION BY ISCHEMIC HYPOXIA2025
  5. 5OS03.6.A POSTSURGICAL ISCHEMIA FOSTERS TUMOR CELL PLASTICITY IN RESIDUAL GLIOBLASTOMA2025