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Oxygen extraction fraction (OEF) has been suggested to be an effective measure to assess the oxygen metabolism and viability of tissue at risk. The preliminary results in a monkey model of stroke demonstrated progressive OEF reduction in both grey matter and white matter after pMCAO, in agreement with the neuron loss and fiber denegation as indicated by diffusion MRI indices following stroke. The findings suggest QSM derived OEF could provide additional information about the oxygen metabolism of the tissue and may be used to assess the ischemia-induced damage of the brain during acute stroke.
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Zhang et al. (2024) studied this question.
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