A Biomechanical Analysis Framework for Co-Correlation of 7T MR Elastography Measures and Amyloid Beta Deposition

Previous studies have implied the future use of MRE metrics to track disease progression and as a tool for AD diagnosis, potentially replacing or augmenting methods that use ionizing radiation. In this pilot study, we have therefore developed a novel framework for performing ultrahigh field (7T) MRE at high resolution on subjects who have previously undergone PET scans and performing joint analysis of biomechanical and pathologic markers on these subjects. We have successfully created a framework for measurement of high-resolution brain mechanical properties for co-correlation with traditional PET measures to be used on AD patients in the future.