We found that the location of the ventral intermediate nucleus (Vim) as determined with dMRI tractography differed only 0.92 mm on average on subsequent scans within the same individual (SD: 0.51 mm) in a test-retest study of 29 healthy individuals. The difference with a commonly used manual method that locates the Vim at fixed distances in relation to the commissures and third ventricular wall was more pronounced: on average 2.44 mm (SD: 0.92 mm). We believe that dMRI tractography based DBS target determination seems feasible and rather accurate, given that acquisition parameters and post-processing are optimal.
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Verhaaren et al. (2024) studied this question.
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