In this exploratory study, we investigated standardized-uptake-values(SUV) from simultaneous bilateral PET-MRI, and individual joint loading in knees cross-sectionally in patients with isolated PFJOA. Additionally, to discover regions of colocalized changes in bone-cartilage interactions, we explored SUV interactions with cartilage biomarker T1rho relaxation values from high-resolution bilateral axial MAPSS. Strong negative correlations were between knee normalized isometric strength vs. maximum SUV in the lateral patella and medial trochlea, suggest higher degree of ongoing bone-remodelling combined with decreased knee flexion and extention strength. The existance of parallel higher trochlear bone remodelling and cartilage loss (disease progression) or vice-versa was also noted.
No takes yet. Share an insight, caveat, or question.
Bhattacharjee et al. (2024) studied this question.