Free-breathing Isotropic resolution self-Navigated B1-insensitive whOle liver simultaneous T1 and T2 mapping (FINO)

Volumetric T1 and T2 relaxation mapping is of interest in the characterization of diffuse and oncological liver diseases. Current methods for free-breathing whole-liver relaxation mapping have primarily been optimized to quantify a water-specific T1, are restricted to large voxel sizes in the feet-head-direction, and are not compatible with self-navigation. The present work proposes a novel methodology for Free-breathing Isotropic resolution self-Navigated B1-insensitive whOle-liver simultaneous water-specific T1 and T2 mapping (FINO). Phantom results illustrate the accuracy of the method and in vivo results demonstrate the feasibility of whole-liver water-specific T1 and T2 mapping at an isotropic resolution of 3mm in 6min.